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47POSTER 34EFFECTS OF CYCLIC BREATHING ON PHYSIOLOGICAL AND PSYCHOLOGICAL STRESS: A CLINICAL INTERVENTIONSERGE ONYPER (SAINT LAWRENCE UNIVERSITY), AMELIA BURKHARD (ST. LAWRENCE UNIVERSITY), GABRIELLE-CATHERINE COTE (ST. LAWRENCE UNIVERSITY), JOSEPH MOCERINE (ST. LAWRENCE UNIVERSITY) This experiment examined the effects of a new controlled breathing technique - cyclic breathing - on stress and well-being in young adults. Participants in the intervention group were instructed to practice cyclic breath daily for one month. On days with more cyclic breathing, participants reported greater feelings of control and ability to carry out their activities and reduced stress and fatigue. Post-treatment, electrophysiology measures revealed enhanced acute stress tolerance for participants in the intervention group.POSTER 35EFFECTS OF LIMITED BEDDING AND NESTING ON ADOLESCENT AND ADULT RAT BEHAVIORGENEVIEVE KOZUB (WASHINGTON COLLEGE), EMMALEE COLE (WASHINGTON COLLEGE), DANIEL KOCHLI (WASHINGTON COLLEGE) This study examines the effects of chronic early life stress (ELS) in 23 Sprague-Dawley rats during adolescence and adulthood. From post-natal day (PND) 2-10, rats and their mother are housed with limited bedding and nesting materials. ELS effects are evaluated through behavioral tasks, fear conditioning, and blood corticosterone levels %u2013 a stress-related biomarker. Data collection is ongoing, with results aimed at informing public health strategies to support new mothers and lessen stress-related developmental challenges.POSTER 36EFFECTS OF SENOLYTIC TREATMENT ON FUNCTIONAL OUTCOMES AFTER EXPERIMENTAL TRAUMATIC BRAIN INJURYCYNTHIA GIBSON (WASHINGTON COLLEGE), LEANDRA BACHE (WASHINGTON COLLEGE), EMMALEE COLE (WASHINGTON COLLEGE), H. MAX MILLER (WASHINGTON COLLEGE), I. KIT YIM (WASHINGTON COLLEGE) Traumatic brain injury (TBI) is a chronic disease process. Senolytic compounds selectively target dysfunctional cells. We investigated functional outcomes after TBI and acute senolytic treatment in rats. TBI resulted in transient motor deficits and balance deficits in senolytic-treated groups three days post-injury. No anxiety, depression, or reference memory effects were found. Working memory results are pending. All tests will be repeated 6, 12, and 18 months post-injury.POSTER 37EFFECTS OF THE PSYCHEDELIC DOI ON RISKTAKING AND IMPULSIVITY IN RATSJUSTUS WILLIAMS (WASHINGTON COLLEGE), DANIEL KOCHLI (WASHINGTON COLLEGE) This study investigates the effect of 2,5-Dimethoxy-4-iodoamphetamine (DOI) on risk-taking behavior and impulsivity in Lewis and Sprague-Dawley rats. While current literature links the serotonergic 2A receptor system to risk-taking behavior and psychedelic effects, their interaction remains unexplored. Behavioral assessments include the elevated plus maze for risktaking and a delayed discounting task for impulsivity, conducted before and after DOI or vehicle administration. Data collection is ongoing, with findings aimed at informing healthcare strategies and societal impacts.POSTER 38EXAMINING THE ROLE OF RODENT SEX DIFFERENCES IN COGNITIVE FLEXIBILITYKYLEIGH LOY (CHRISTOPHER NEWPORT UNIVERSITY), OWEN HENKE (CHRISTOPHER NEWPORT UNIVERSITY), ALLISON MALMQUIST (CHRISTOPHER NEWPORT UNIVERSITY), OLGA LIPATOVA (CHRISTOPHER NEWPORT UNIVERSITY) Flexibility is a fundamental cognitive function that allows organisms to adapt to changing conditions. To explore these processes, we employed visual discrimination and reversal learning tasks in female and male rats. Our findings reveal sex differences inthe acquisition of both initial discrimination and reversal learning. These results suggest that distinct subregions of the medial prefrontal cortex (mPFC) may be differentially modulated by gonadal hormones in males and females.POSTER 39EXPLAINING NEUROPSYCHOLOGICAL DISORDERS THROUGH THE GUT-BRAIN AXIS: THE ROLE OF INFLAMMATIONYUKTHA SHANAVAS (SUNY UPSTATE MEDICAL UNIVERSITY , BINGHAMTON UNIVERSITY), SAMANTHA BALLAS (SUNY UPSTATE MEDICAL UNIVERSITY, BINGHAMTON UNIVERSITY), ALIZEH KHAN 47Friday, March 7