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48(BINGHAMTON UNIVERSITY), IAN MCDONOUGH (STATE UNIVERSITY OF NEW YORK, BINGHAMTON UNIVERSITY) The gut microbiome describes the collection of microorganisms residing in the intestines. It serves several functions, including maintaining emotional and cognitive health. This review examines how gut dysbiosis, an imbalance of intestinal microorganisms, contributes to neuropsychological disorders. We found that the gut-brain axis contributes to peripheral and neuroinflammation that are at the root of many neuropsychological disorders. We also consider lifestyle modifications to prevent or treat neuropsychological disorders through the gut-brain axis.POSTER 40EXPLORING INTERACTIONS BETWEEN THE CIRCADIAN RHYTHM SYSTEM AND SEX ON ALCOHOL SEDATIONELIZABETH HANLON (WESTFIELD STATE UNIVERSITY), PRINCY QUADROS-MENNELLA (WESTFIELD STATE UNIVERSITY) Circadian rhythm dysfunction may influence behavioral and physiological symptoms of alcohol consumption, potentially increasing alcohol addiction, a relationship also observed in Drosophila melanogaster. We investigated the interaction between the circadian rhythm system and sex on alcohol sedation in Drosophila, since sexual dimorphisms in alcohol sedation have been observed. Preliminary results suggest speed of alcohol sedation is mediated by sex and circadian rhythm mutations. We plan to run more trials to verify preliminary findings.POSTER 41EXPLORING THE EFFICACY OF RPVT ON THE MK801 NEURODEVELOPMENTAL SCHIZOPHRENIA MODELCAROLINE DRUPKA (WASHINGTON COLLEGE), KATRINA CALLAHAN (WASHINGTON COLLEGE), DANIEL KOCHLI (WASHINGTON COLLEGE) This study investigates the efficacy of the rodent Psychomotor Vigilance Test (rPVT) on the MK-801 neurodevelopmental Schizophrenia model in 27 LongEvans rats. People with schizophrenia often have executive dysfunction, especially regarding sustained attention. Previous literature has indicated attentional deficits in this model, but they have not been measured using rPVT. This paradigm's efficacy will be measured based on the rats' abilities to progress through each session while also being compared to the control.POSTER 42GLP-1 RECEPTOR AGONISTS, GASTRIC MALAISE, AND PREVENTION OF WEIGHT GAIN IN RATSCHARLOTTE AIROSUS (AMERICAN UNIVERSITY), TERRY DAVIDSON (AMERICAN UNIVERSITY), ALEXIA HYDE (UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES), NINA ARDABILI (AMERICAN UNIVERSITY) The GLP-1 agonists liraglutide and semaglutide produce significant weight loss in people with obesity, but their ability to prevent weight or body fat gain caused by consuming energy-rich Western-style diets (WDs) has not been investigated. Our study found that rats fed WD gained significantly more body weight and adiposity compared to chow-fed controls. However, there was little evidence that either drug reduced these WD effects at doses that failed to produce conditioned taste avoidance.POSTER 43INACTIVATION OF HIPPOCAMPAL-FRONTAL CIRCUITY DURING A TOUCHSCREEN-BASED SPATIAL WORKING MEMORY TASKISABELLA BOXER (LAFAYETTE COLLEGE), OLIVIA CHIOCCARIELLO (LAFAYETTE COLLEGE), LAUREN KARWACKI (LAFAYETTE COLLEGE), CATHERINE SOERGEL (LAFAYETTE COLLEGE), JULIA SEALING (LAFAYETTE COLLEGE), IRELYND LORENZEN (LAFAYETTE COLLEGE), FINIAN ZAKAS (LAFAYETTE COLLEGE), NELLY FADIL (LAFAYETTE COLLEGE), ABIGAIL HARR (LAFAYETTE COLLEGE), HENRY HALLOCK (LAFAYETTE COLLEGE) Rodent spatial working memory tasks often engage hippocampal-frontal circuits, unlike primate tasks. Using the touchscreen-based TUNL task, we found that inactivating this circuit reduced accuracy for closely spaced objects but not for longer delays. This suggests spatial proximity, not delay, drives hippocampal involvement and supports TUNL's preclinical utility.POSTER 44INSULA-FRONTAL CORTICAL INTERACTIONS DURING A TOUCHSCREEN-BASED ATTENTION TASK (RCPT) IN MICEMATTHEW O'LEARY (LAFAYETTE COLLEGE), ABIGAIL HARR (LAFAYETTE COLLEGE), EVA MEI VOGT (LAFAYETTE COLLEGE), HENRY HALLOCK (LAFAYETTE COLLEGE) We investigated the neural mechanisms of attention in a rodent continuous performance test (rCPT). Using dual viral targeting, we identified the anterior insula as part of a broader network involving the locus coeruleus 48